Method details

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Accurate Lumen Segmentation and Stenosis Detection and Quanti cation in Coronary CTA



Abstract:
Accurate detection and quanti cation of coronary artery stenoses is fundamental in correct patient diagnosis and optimal treatment planning. Central to detection and quanti cation is the correct estimation of lumen in the coronary vessel. Here, we describe a method for accurate lumen segmentation in CTA and present results of an early prototype for stenosis detection and quanti cation for a variety of datasets. For the detection, a sensitivity of 72% and a PPV of 17% is obtained as compared to QCA, while a sensitivity of 57% and a PPV of 18% is achieved as compared to CTA. The stenosis degree is estimated with an absolute average di erence of 49% as compared to QCA, and a weighted kappa value of -0.15 is obtained as compared to CTA. A Dice of 73% and 69% is reported for lumen segmentation of healthy and diseased vessel segments respectively.

Detection confusion tables

Calc. cat.QCA (per segment)CTA (per lesion)
 TPFPFNTP+FPTP+FNTPFPFNTP+FPTP+FN
All  16  95  12  111  28  24  129  23  153  47 
The results of this method are based on the following centerlines: Rcadia team auto.

Detection (QCA per segment / CTA per lesion)

Calc. cat.QCA
Sens.
QCA
P.P.V.
CTA
Sens.
CTA
P.P.V.
Avg. rank
 %rank%rank%rank%rank 
0 (0 - 0.1)  80.0  1.0  16.0  9.0  71.4  3.0  13.9  12.0  6.2 
1 (0.1 - 10)  100.0  1.0  7.1  13.0  60.0  6.0  15.8  11.0  7.8 
2 (11 - 100)  71.4  4.0  17.2  12.0  54.5  8.0  14.3  12.0  9.0 
3 (101 - 400)  60.0  8.0  20.0  11.0  47.4  9.0  22.0  10.0  9.5 
4 (400+)  0.0  19.0  0.0  19.0  20.0  17.0  6.7  17.0  18.0 
All  57.1  7.0  14.4  13.0  51.1  7.0  15.7  13.0  10.0 
For ranking  57.1  7.0  14.4  13.0  51.1  7.0  15.7  13.0  10.0 
These results are based on 30 datasets and 19 submissions.


Quantification

Calc. cat.QCA
Avg. Abs. diff.
QCA
R.M.S. diff.
CTA
Weigthed Kappa
Avg. rank
 %rank%rankΚrank 
0 (0 - 0.1)  45.4  11.0  53.0  13.0  0.12  12.0  12.0 
1 (0.1 - 10)  47.5  13.0  54.0  14.0  0.16  11.0  12.2 
2 (11 - 100)  49.0  12.0  54.5  12.0  0.13  11.0  11.5 
3 (101 - 400)  48.9  12.0  55.1  12.0  0.18  11.0  11.5 
4 (400+)  66.7  14.0  70.7  14.0  0.23  12.0  13.0 
All  49.6  12.0  56.0  15.0  0.15  12.0  12.8 
For ranking  49.6  12.0  56.0  15.0  0.15  12.0  12.8